2b:null 2c:["$","title",null,{"children":"Estimating Librela’s Half-Life | d8abased | Observable"}] 31:T446,If you suspect that your dog or your canine patient has suffered an adverse drug reaction (sADR) to Librela, your first question will likely be, _“How can I get this drug out of this dog’s body?”_ The unfortunate reality is that there’s no known, guaranteed way to expedite this process: you have to wait it out as the body degrades the monoclonal antibody, and disposes of it. The metabolic pathway of Librela has not been studied by Zoetis as noted under their _Pharmacokinetics_ section in their _[Prescribing Information](https://www.zoetisus.com/content/pages/products/dogs/Librela/Resources/documents/Librela-prescribing-information.pdf)_: > _The metabolic pathway of bedinvetmab has not been characterized. As a canine IgG monoclonal antibody, bedinvetmab is expected to be degraded into small peptides and amino acids via catabolic pathways in a manner similar to endogenous IgG._ So, the next natural question that comes to mind is, _“When will Librela leave my dog’s body, and how much does it matter?”_ Here we can provide better answers, including a way to estimate.32:T40a,The term [**half-life** `t½`](https://en.wikipedia.org/wiki/Half-life) refers to the amount of time it takes for the concentration of a drug in the body to reduce by half. For example, consider a medication with a half-life of 19 days. If you take a dose of this medicine, theoretically, 19 days later, only half of the drug’s original amount will remain in your body. After another 19 days (totaling 38 days from the initial dose), its concentration in your body will be reduced by another half, meaning only about one quarter of the original dose will be left. And so on for subsequent 19-day increments until the drug’s concentration in your body gets to 0%. A longer half-life means the drug stays in the body longer, potentially requiring less frequent dosing. Conversely, a short half-life might require more frequent administration of a drug to maintain its therapeutic effect. Understanding half-life helps ensure that a medication is used safely and effectively, maintaining the desired balance in the body over time.33:T43f,

t½

10.8d

19.1d

27.4d

34:T12d1,Plot.plot({ width: width, marginTop: 20, marginBottom: 100, insetBottom: 20, insetTop: 20, insetLeft: 20, height: 720, y: {percent: true, tickFormat: d => d + "%", zero: true, label: "Concentration relative to first dose peak serum", domain: [-1, controls.total_shots > 6 ? 190 : controls.total_shots > 2 ? 180 : controls.total_shots > 1 ? 150 : 100], grid: false}, x: {interval: null, domain: domain}, marks: [ // Plot.gridX({ // interval: "week" // }), Plot.areaY(data.decay, {x: d => d.cMed >= 0.0095 ? d.date : null, y1: -0.01, y2: 2, fill: "red", fillOpacity: 0.1}), Plot.areaY(data.decay, {x: d => d.cMed <= 0.0099 ? d.date : null, y1: -0.01, y2: 2, fill: "#fbfbfb"}), // Plot.areaY(data.decay, {x: d => d.cMed > 0.009 ? d.date : null, y1: -0.01, y2: 1.175, fill: "black", fillOpacity: 0.04}), // Plot.ruleY(data.decay, {x1: domain.at(0), x2: d => d.cMed > 0.01 ? d.date : null, y: 1.175, dx: 4, stroke: "#eeeeee", strokeWidth: 0.5}), // Plot.text(data.decay, {x: "date", y: 1.175, text: d => d.phaseshift == true ? "mean steady state" : null, monospace: true, fontSize: 9, fontWeight: 600, stroke: "white", fill: "black", strokeOpacity: 1, strokeWidth: 2, textAnchor: "end", dx: -30}), // Plot.areaY(data.decay, {x: "date", y1: -0.01, y2: "cSlow", fill: "red", fillOpacity: 0.05}), // Plot.areaY(data.decay, {x: "date", y1: -0.01, y2: "cMed", fill: "black", fillOpacity: 0.05}), // Plot.areaY(data.decay, {x: "date", y1: -0.01, y2: "cFast", fill: "green", fillOpacity: 0.05}), Plot.axisX({ // anchor: "top", tickRotate: -90, tickSize: 10, interval: controls.total_shots > 10 ? "month" : controls.total_shots > 5 ? "2 weeks" : "week", tickFormat: d => d.toLocaleDateString('en-US', { day: 'numeric', month: 'short', year: 'numeric', timeZone: "UTC" }) }), Plot.text(data.decay, {x: "date", y: controls.total_shots > 6 ? 1.9/2 : controls.total_shots > 2 ? 1.8/2 : controls.total_shots > 1 ? 1.5/2 : 1/2, text: d => d.phaseshift == true ? "↓ 1% remaining (avg)" : null, textAnchor: "middle", monospace: true, fontSize: 9, fontWeight: 600, stroke: "white", fill: "black", strokeOpacity: 1, strokeWidth: 2, rotate: -90, dx: 3}), // Plot.ruleX(d3.filter(data.decay, (d) => d.cFast > 0.009), {x: "date", y: 0.02, dy: 14, stroke: "green", strokeWidth: 1, strokeOpacity: 0.5}), // Plot.ruleX(d3.filter(data.decay, (d) => d.cFast < 0.009 & d.cMed > 0.009), {x: "date", y: 0.02, dy: 14, stroke: "black", strokeWidth: 2, strokeOpacity: 0.5}), // Plot.ruleX(d3.filter(data.decay, (d) => d.cMed < 0.009 & d.cSlow >= 0), {x: "date", y: 0.02, dy: 14, stroke: "red", strokeWidth: 1, strokeOpacity: 0.5}), Plot.lineY(data.decay, {x: "date", y: "cFastest", stroke: "green", strokeOpacity: 0.33, strokeDasharray: [1, 1], curve: "step"}), // Plot.lineY(data.decay, {x: "date", y: "cFast", stroke: "teal", strokeOpacity: 0.33, strokeDasharray: [], curve: "step"}), Plot.lineY(data.decay, {x: "date", y: "cSlow", stroke: "red", strokeOpacity: 0.5, strokeDasharray: [], curve: "step"}), Plot.lineY(data.decay, {x: "date", y: "cMed", stroke: "black", strokeWidth: 2, strokeOpacity: 1, curve: "step"}), Plot.ruleX(data.decay, Plot.pointerX({x: "date", y1: -0.07, y2: 2, stroke: "black", strokeOpacity: 1, strokeWidth: 1, opacity: 0.5, textFillOpacity: 0}) ), Plot.dotX( data.decay, Plot.pointerX({ x: "date", y: "cFastest", fill: "green", r: 3, }) ), // Plot.dotX( // data.decay, // Plot.pointerX({ // x: "date", // y: "cFast", // fill: "teal", // r: 3, // }) // ), Plot.dotX( data.decay, Plot.pointerX({ x: "date", y: "cSlow", fill: "red", r: 3, }) ), Plot.dotX( data.decay, Plot.pointerX({ x: "date", y: "cMed", fill: "black", r: 3, }) ), // Tip Plot.tip(data.decay, Plot.pointerX({ x: "date", y: 0.1, pointerSize: 0, fill: "white", fillOpacity: 0.80, monospace: true, title: (d) => `Day ${Math.round((new Date(d["date"]) - controls.last_administered) / (24 * 60 * 60 * 1000))} | ${new Date(d["date"]).toLocaleDateString('en-US', { timeZone: "UTC", month: 'short', day: 'numeric', year: 'numeric' })}\n\n27.4d: ${d3.format(".2%")(d.cSlow)}\n19.1d: ${d3.format(".2%")(d.cMed)}\n10.8d: ${d3.format(".2%")(d.cFastest)}` })), // Shot labels Plot.text(data.decay, {x: "date", y: "cMed", text: d => d.administered != 0 ? d.administered : null, dy: 0, lineAnchor: "bottom", monospace: true, fontSize: 10, fontWeight: 600, stroke: "black", fill: "white", strokeOpacity: 1, dy: 12, strokeWidth: 4}), ] })35:Tcd1,

Study	Population	n (Librela)	Dose	Administration	t½ (per Zoetis)	t½ (per FDA)	t½ (per EMA)	t½ (per HC)
6-month Safety Study	10 to 12 month-old healthy laboratory Beagles	24	1 to 10 mg/kg	every 28 days x 7 doses	9.5 ± 1.8 days	8.8-10 days	~12 days	~13 days
US Field Study	Select ≥1 year-old client-owned dogs with OA	135	0.5 to 1 mg/kg	every 28 days x 3 doses	19.1 ± 8.3 days	~19 days	NR	19 ± 8 days
EU Field Study	Select ≥1 year-old client-owned dogs with OA	141	0.5 to 1 mg/kg	every 28 days x 3 doses	NR	NR	~16 days	NR

36:Tdd4,// This function generates the decay of Librela in a dog given the initial shot date and number of shots function generateDecay(last_shot_date, number_of_shots) { // Duration to achieve peak serum levels after administration const rampUpDays = 9.3; // Maximum loop iterations to prevent infinite loops (only needed for debugging but no harm leaving in) const maxIterations = 10000; // Calculate decay factor based on half-life function getDecayFactor(days, half_life) { return Math.pow(0.5, days / half_life); } // Helper function to add days to a date function addDays(date, days) { let result = new Date(date); result.setDate(result.getDate() + days); return result; } let shots = []; let lastShotDate = new Date(last_shot_date); // Create shot objects for each shot based on initial shot date and interval for (let i = 0; i < number_of_shots; i++) { // Calculate the date for each shot assuming a 30-day interval let shotDate = addDays(lastShotDate, -i * 30); shots.push({ date: shotDate, serumConc: 0, completed: false }); } // Sort shots by date in ascending order shots.sort((a, b) => a.date - b.date); let result = []; let currentDate = new Date(shots[0].date); let totalAmountSlow = 0; let totalAmountMed = 0; let totalAmountFast = 0; let totalAmountFastest = 0; let shotIndex = 0; let phaseShiftOccurred = false; let iterationCount = 0; // Process each day until all doses are fully administered or maximum iterations are reached while ((totalAmountSlow > 0.005 || shots.some(shot => !shot.completed)) && iterationCount < maxIterations) { iterationCount++; let administered = 0; let phaseShift = false; // Add to serum daily shots.forEach(shot => { if (currentDate.getTime() > shot.date.getTime() && shot.serumConc < 1 && !shot.completed) { let currSerumConc = 1 / rampUpDays; shot.serumConc += currSerumConc; if (shot.serumConc >= 1) { shot.completed = true; } totalAmountSlow += currSerumConc; totalAmountMed += currSerumConc; totalAmountFast += currSerumConc; totalAmountFastest += currSerumConc; } }); // Check if a new shot is administered on the current date if (shots.some(shot => shot.date.getTime() === currentDate.getTime())) { shotIndex++; administered = shotIndex; } // Trigger a phase shift based on medium decay amount conditions // Note totalAmountMed == 0 on day 0, so we don’t terminate that soon if (!phaseShiftOccurred && totalAmountMed <= 0.01 && totalAmountMed > 0) { phaseShift = true; phaseShiftOccurred = true; } // Apply decay factors based on half-lives totalAmountSlow *= getDecayFactor(1, 27.4); totalAmountMed *= getDecayFactor(1, 19.1); totalAmountFast *= getDecayFactor(1, 15.8); totalAmountFastest *= getDecayFactor(1, 10.8); // Store daily results result.push({ date: new Date(currentDate), cSlow: totalAmountSlow, cMed: totalAmountMed, cFast: totalAmountFast, cFastest: totalAmountFastest, administered: administered, phaseshift: phaseShift }); // Increment the current date currentDate = addDays(currentDate, 1); } // Check if the loop exited due to reaching the maximum iterations if (iterationCount >= maxIterations) { console.warn('Max iterations reached, check for potential infinite loop conditions.'); } return { decay: result }; } 37:[] 2f:{"id":"3e3198fa7add9224","slug":"halflife","title":"Estimating Librela’s Half-Life","thumbnail":"e0c06409ab5a83ba8fefd3c13d846fc4bfe37ca354f582477d8470ade8c773d5","access_level":"public","create_time":"$D2024-07-22T20:43:43.176Z","update_time":"$D2024-10-04T00:26:21.061Z","view_time":null,"first_public_time":"$D2024-07-31T20:00:15.248Z","fork":false,"stars":1,"starred":false,"owner":{"type":"team","id":"387bada7be81c746","login":"d8abased","name":"d8abased","avatar_url":"https://avatars-next.observableusercontent.com/5680b5bdb4c31365df3342e07cb358027698748c24682dbd4476d6e8cc3e9e82","tier":"starter_2024"},"version":1832,"publish_version":null,"role":null,"authored":false,"authors":[{"type":"individual","id":"ad011ae0dc79cf45","login":"d8abased","name":"the d8a team","avatar_url":"https://avatars-next.observableusercontent.com/70386b934552f1ef82ce5a323c14a14824b8e72ac7d241df9ecb75c85c27608b","tier":null}],"members":[{"type":"team","id":"387bada7be81c746","login":"d8abased","name":"d8abased","avatar_url":"https://avatars-next.observableusercontent.com/5680b5bdb4c31365df3342e07cb358027698748c24682dbd4476d6e8cc3e9e82","tier":"starter_2024","role":"editor"},{"type":"individual","id":"ad011ae0dc79cf45","login":"d8abased","name":"the d8a team","avatar_url":"https://avatars-next.observableusercontent.com/70386b934552f1ef82ce5a323c14a14824b8e72ac7d241df9ecb75c85c27608b","tier":null,"role":"editor"}],"comments":[],"custom_thumbnail":true,"trashed":false,"subscribed":null,"forks":2,"collection":{"id":"8e2a9ac146d4c315","slug":"librela","title":"Librela","owner":{"id":"387bada7be81c746","login":"d8abased","name":"d8abased"}},"type":"notebook","body":{"title":"Estimating Librela’s Half-Life","cells":[{"id":0,"value":"# Estimating Librela’s Half-Life\n## “How much Librela is left in my dog? And how much does it matter?”","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":588,"value":"---","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":962,"value":"renderMenu()","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":866,"value":"$31","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":871,"value":"## What is Half-life?","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":873,"value":"$32","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":637,"value":"## Estimate Your Dog’s Librela Half-Life","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":833,"value":"The Librela half-life estimator provides a projection of the remaining concentration of Librela in the body _n_ days after the final injection. It is modeled from publicly available information from the limited studies conducted by Zoetis. Its goal, as its name implies, is to provide a _useful_ estimate for Librela clearance.\n\n#### Instructions \nSelect the date your dog received their last injection, and enter the total number of injections they received. The estimator will back-populate an injection schedule at 30-day intervals (with each injection numbered), and present you with a decay chart for various half-life values (more on that later). You can hover over the chart to get estimated concentrations remaining for any particular day.","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":750,"value":"viewof controls = Inputs.form(\n {\n last_administered: Inputs.date({label: \"Last administered\", value: \"2024-03-06\", required: true}),\n total_shots: Inputs.range([1,d3.timeMonth.count(new Date(2021, 2), new Date())], {label: \"Total shots given\", minimum: 1, step: 1, value: 4, width: 240})\n },\n {\n template: (inputs) => htl.html`\n

${inputs['last_administered']}

${inputs['total_shots']}

\n `\n }\n)","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":677,"value":"$33","pinned":false,"hidden":false,"mode":"html","author":"$undefined","summary":"$undefined"},{"id":25,"value":"$34","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":1650,"value":"

📝 Peak Serum Concentration
Since Librela is administered subcutaneously it takes a few days ([9.3 ± 3 days](https://www.sciencedirect.com/science/article/pii/S1467298723001034)) to achieve peak serum concentration after the administration of each dose. For the sake of simplicity, we only use the average value of _9.3d_. But it is worth noting that many dogs will absorb Librela quicker, say in _6.3 days_, and clear it slower, say t½ of _27 days_—the pharmacokinetics of Librela in these dogs will further deviate from what this estimator can capture. \n

","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":836,"value":"## Why Are There Multiple Half-Life Curves?","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":838,"value":"By Zoetis’s own admission, the half-life of Librela is highly variable.\n\nFrom the official [_Librela Prescribing Information_](https://www.zoetisus.com/content/pages/products/dogs/Librela/Resources/documents/Librela-prescribing-information.pdf):\n\n> _In a laboratory pharmacokinetic study in Beagles at 0.5-1.0 mg/kg, peak serum drug levels were observed at 4-7 days after subcutaneous dosing, the mean bioavailability relative to an intravenous dose was approximately 86%, and **the elimination half-life was approximately 12 days**._
\n> \n> _In a field study at the labeled dose in dogs with osteoarthritis, **the half-life was highly variable and\naveraged approximately 19 days (harmonic mean 15.8 days)**. Steady-state was achieved after 2 doses._","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1066,"value":"A compilation of the various half-life values reported across all the official sources truly demonstrates not only the variability, but also the inconsistent half-life documentation across the small number of Librela studies Zoetis has conducted:","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1051,"value":"$35","pinned":false,"hidden":false,"mode":"html","author":"$undefined","summary":"$undefined"},{"id":1064,"value":"At the time of this writing, **July 27, 2024**, it is not known how quickly an individual dog will clear Librela. But it is fair to assume that Librela recipients in the real world are unlikely to clear Librela as fast as the 10-12 month-old healthy laboratory Beagles in the above table. It is thus best to ignore that row entirely in our half-life estimation discussions. \n\nThis leaves us with the remaining two rows resulting in _3_ half-life decay lines from fastest to slowest clearance, all from Zoetis’s US Field Study (see table above): \n> `10.8d` _i.e. 19.1 minus 8.3_
\n> **`19.1d`** _i.e. the average_
\n> `27.4d` _i.e. 19.1 plus 8.3_","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":987,"value":"

📝 Zoetis’ 60-80d rule of thumb clearance advice to veterinarians & dog parents
Online accounts from dog owners/veterinarians have reported being informed by Zoetis employees that Librela takes somewhere between 60-80 days to be eliminated. This range is roughly equivalent to the _10.8d_ half-life concentration dropping to ~_1-3%_. As the Estimator above demonstrates, this is likely the absolute best case scenario. Most dogs will take much longer to clear the drug, with an average of over 100 days (_i.e. t1/2 of 19.1d_). Thus, based on Zoetis’ own evidence and statistical best practices, **we recommend _against_ using 60-80d for prognostic purposes**.\n

","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1106,"value":"## The 5 Half-Life Rule","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1108,"value":"There exists an informal and established _[5 half-life rule of thumb](https://www.merckvetmanual.com/pharmacology/pharmacology-introduction/pharmacokinetics)_ in pharmacokinetics. \n\nThis rule of thumb suggests that a drug is considered to be effectively eliminated from the body after approximately five half-lives, as about 97% of it will have been metabolized or excreted. It is useful for simplifying the understanding of drug elimination, aiding clinicians in estimating dosing intervals and predicting drug clearance times. However, this rule of thumb along with the concept of half-life itself have several limitations that can complicate its practical application.\n","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1406,"value":"[Half-life does not account for all variables affecting drug kinetics](https://derangedphysiology.com/main/cicm-primary-exam/required-reading/pharmacokinetics/Chapter%20322/half-life). Factors such as the volume of distribution, clearance rate, and the presence of active metabolites can significantly alter drug behavior in the body. For example, drugs with a large volume of distribution may remain in tissues and be slowly released back into circulation, prolonging their effective presence despite their plasma half-life. Physiological conditions such as renal or hepatic impairment can drastically change the half-life.","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1301,"value":"Further, assuming that a drug no longer affects the body after five half-lives is incorrect. Drugs with long half-lives may still maintain therapeutic or toxic effects beyond this period due to their prolonged presence in body compartments like fat or muscle. Even trace amounts of a drug can exert pharmacological effects, especially if the drug or its metabolites have a high affinity for their targets.\n\nTherefore, while the 5 half-life rule is a useful general guideline, it is far from a comprehensive tool for understanding drug kinetics and should be applied with caution, considering the specific pharmacological properties and patient conditions.","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1298,"value":"

👍 A Better Rule of Thumb
If you must use a rule of thumb, we recommend a more realistic range:
`110-160d` since the last injection

This range is derived from the estimated Librela concentrations falling roughly below 3% for average & slow clearing dogs (the black & red lines on the Estimator), assuming two injections, 30 days apart. It accounts for the highly variable half-life range, the real-world population, and insights from real-world sADR surveillance data.

","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1320,"value":"## In Conclusion","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1311,"value":"Half-life isn’t a panacea.\n\nIt is merely one metric we can use to gauge the state of a dog who has experienced a Librela sADR and is being monitored for sequelae. Dr. Michael Farrell articulates some of these ideas in his _[VetLessons on Librela](https://www.facebook.com/groups/3299613933662015)_ group.\n\nFrom the thousands of case-studies shared by pet owners and veterinarians online, many dogs seem to recover fully much earlier than Librela hitting _0%_ on any of the half-life curves; other dogs reportedly continue to have flare-ups with symptoms ebbing and surging and even new symptoms presenting well into the fifth and sixth months after their last Librela injection. Yet others reportedly develop new disabling and even terminal health conditions well past full clearance of Librela. \n\nIn conclusion, factor the half-life curve into the overall clinical presentation judiciously. It can be a helpful tool, but it is just that: _a tool_. \n\nHopefully you are now equipped to use it well. 🐾","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":968,"value":"cellFooter","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":1792,"value":"cellDataLoaders","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":7,"value":"$36","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":16,"value":"data = generateDecay(controls.last_administered, controls.total_shots);","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":388,"value":"domain = d3.extent(data.decay, d => d.date)","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":932,"value":"import {cellStyles} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":1790,"value":"import {cellDataLoaders} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":935,"value":"cellStyles","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":938,"value":"import {openSomeLinksInNewTab} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":941,"value":"openSomeLinksInNewTab","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":946,"value":"import {ga} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":949,"value":"ga('G-Y70GS4M3D7');","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":953,"value":"import {cfa} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":956,"value":"cfa()","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":959,"value":"import {renderMenu} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":965,"value":"import {cellFooter} from \"@d8abased/introduction\"","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"}],"files":"$W37","stdlib":"1","titling":"auto"}} 30:"$2f:body"