2b:null 2c:["$","title",null,{"children":"An Introduction to Librela sADRs | d8abased | Observable"}] 31:Tbcd, While EVVet provides a dashboard and the ability to download the data, its user experience is challenging and not for the faint of heart. This resource is a collection of _interactive_² notebooks that breaks the rich EVVet dataset out of its confines into the [Open Web](https://www.w3.org/wiki/Open_Web_Platform) so that important work and discussion may begin in analyzing the suspected impact of Librela in the wild. Needless to say, [the content of the data is preserved](https://observablehq.com/@d8abased/introduction#cellFooter)—the data here is identical to the EVVet data. These notebooks are aimed at everyone from veterinary professionals and researchers to journalists and pet owners: > [📘📈 **A Visual Tour of the Librela sADR Data →**](https://librela.d8abased.com/explore)
Here we provide the reader with a higher-level grasp of the Librela sADR data using easy-to-digest visualizations and statistics > [📘🔎 **Search & Download the Librela sADR Data →**](https://librela.d8abased.com/search)
Here we make the data available for fast search and download to help with diagnostics and further research > [📘🩸 **Why Librela’s Adverse Reaction Rate is Probably Higher Than 0.18% →**](https://librela.d8abased.com/incidenceintro)
Here we demonstrate (a) how Zoetis likely calculated the 0.18% sADR incidence rate, (b) why it’s likely an underestimate, and (c) why the actual incidence rate is probably much higher. Additionally, we provide a notebook that helps estimate how long it takes Librela to leave a dog’s system and how to reason about half-life in the prognostic journey: > [📘🧪 **Estimating Librela’s Half-Life →**](https://librela.d8abased.com/halflife)
Here we help you answer the questions, _“How much Librela is left in my dog? And how much does it matter?”_

¹Librela, a product of [Zoetis, Inc.](https://zoetis.com), is also sold under the name _Beransa_ in Australia. Both, _Librela_ and _Beransa_ are brandnames for the active ingredient _Bedinvetmab_.
²Unlike a static web page, this page (aka notebook) is _“live”_. All the numbers (even within sentences) and charts you see on the page are calculated in real-time from the EVVet data when the page is loaded. The entire notebook also dynamically updates whenever new data becomes available. In other words, you can bookmark this notebook and revisit it from time to time to see updated data, charts, etc. [Observable](https://observablehq.com/) notebooks like this one serve the dual purpose of being blog posts _and_ data dashboards.

32:T5bb,Analyzing sADR data is particularly tricky due to the various complicating factors involved in creating the data: life & death stakes, profits, interpersonal politics & competing cognitive biases, technical limitations of real-world surveillance, incompleteness of the reports, etc. Take just one overlooked facet of such analyses: **the underreporting of sADRs**. Indeed, the scientific literature has consistently found that **[over 9 out of 10 sADRs are never reported](https://pubmed.ncbi.nlm.nih.gov/16689555/)** — and that’s for _humans_. Expectedly, it’s **[significantly worse](https://bvajournals.onlinelibrary.wiley.com/doi/10.1136/vetreco-2017-000224)** for veterinary patients. Additionally, our brains will often reach for over-simplifications, leading to thought-ending clichés like, _“Correlation is not causation!”_ or _“The numbers don’t lie!”_. Data analysis demands a kind of disciplined reasoning that is often in opposition to our intuition; our intuition, on the other hand, drives us to question what we see in the first place, especially when an important pattern may be emerging, and it is where real science usually begins. [Both systems of thinking](https://en.wikipedia.org/wiki/Thinking,_Fast_and_Slow) are crucial to this process, and we hope that you will keep this in mind as you explore the data. With that out of the way, grab a seat and pick a notebook to navigate to in the _Table of Contents_ right below. 🐾33:T22a9,

Meta Information

How the Data is Prepared

Provenance of the original EVVet data, including the contents of each cell, is considered sacred and treated as immutable. Our end-to-end process involves minimal merging, sanitizing, and augmenting of the data to facilitate analysis as follows:

We did a one-time download of the VeDDRA xlsx file linked on page 2 here, and converted it to a csv while filtering out human terms. The resulting data/output/veddra.csv file is used later; you can see the trivial notebook that does that work here: data/veddra.ipynb.
Next we download csv files from EVVet’s Line Listing Tool. This results in multiple csv files (split by year) that you can find in data/input/evvet/.
The data/fetch-evvet-data.ipynb python notebook then iterates through all the source csv files, sanitizes them (concatenate, rearrange columns, drop duplicates, etc.), generates the data/output/evvet_master.csv output file, and spits out some validation stats to ensure parity with EVVet (which is the source of truth).
evvet_master.csv is then loaded via a CORS proxy into a data variable in this notebook.
A combination of JavaScript, HTML, CSS, Markdown, Observable Plots, and APIs like D3 are used to transform the data as necessary to feed the lazy-loaded, static content blocks in this notebook.

The first three steps are repeated as and when EVVet pushes out more data.

Note On occasion EVVet’s dashboard reflects incorrect metrics as it seems to have a bug whereby the graphs lag a full data update, i.e. the graphs reflect the data from their prior update. We are working on filing a bug against their system to rectify this.

🐙 Fork on Github
The full repository including the source files, fetch/merge code, etc. is available publicly on Github. Feel free to peruse, clone, fork, etc: https://github.com/d8abased/librela

About Us

These notebooks are an ongoing project by volunteer data & computer scientists, with contributions from graphic designers, editors, healthcare professionals, veterinary professionals, and even a geographer. The authors and contributors all have dogs. Some of these dogs have taken Librela, while others’ haven’t; some of these dogs have fared well on Librela, while others have experienced adverse reactions. While the members of this global, interdisciplinary team come from different walks of life, they all share a penchant for data and details.

And of course, dogs. 🐶

📮 Questions or Concerns?
Feel free to contact us at d8abased@gmail.com.

34:T40c,ga = UA => { const script = document.createElement('script'); const location = html``; script.src = 'https://www.googletagmanager.com/gtag/js?id=' + UA; script.type = 'text/javascript'; script.async = true; script.onload = () => { window.dataLayer = window.dataLayer || []; function gtag() { var dataLayer = window.dataLayer; dataLayer.push(arguments); } gtag('js', new Date()); gtag('config', UA, { 'page_path': location.pathname, 'page_location': location.href }); }; document.body.appendChild(script); } // Solution 2 // ga1 = { // const ua = 'G-Y70GS4M3D7'; // await require(`https://www.googletagmanager.com/gtag/js?id=${ua}`).catch(() => {}); // const dataLayer = window.dataLayer = window.dataLayer || []; // const location = html``; // gtag('js', new Date()); // gtag('config', ua, { // 'page_path': location.pathname, // 'page_location': location.href // }); // function gtag() { dataLayer.push(arguments); } // }35:Tfa9,36:[] 2f:{"id":"1f288acd737acdf4","slug":"introduction","title":"An Introduction to Librela sADRs","thumbnail":"e88754711bb6b2ba3d60a89975ec1eaee670ed369ec0144ef20177810305f812","access_level":"public","create_time":"$D2024-07-12T00:01:39.333Z","update_time":"$D2024-10-06T21:53:01.299Z","view_time":null,"first_public_time":"$D2024-07-12T01:16:54.160Z","fork":true,"stars":0,"starred":false,"owner":{"type":"team","id":"387bada7be81c746","login":"d8abased","name":"d8abased","avatar_url":"https://avatars-next.observableusercontent.com/5680b5bdb4c31365df3342e07cb358027698748c24682dbd4476d6e8cc3e9e82","tier":"starter_2024"},"version":5286,"publish_version":null,"role":null,"authored":false,"authors":[{"type":"individual","id":"ad011ae0dc79cf45","login":"d8abased","name":"the d8a team","avatar_url":"https://avatars-next.observableusercontent.com/70386b934552f1ef82ce5a323c14a14824b8e72ac7d241df9ecb75c85c27608b","tier":null}],"members":[{"type":"team","id":"387bada7be81c746","login":"d8abased","name":"d8abased","avatar_url":"https://avatars-next.observableusercontent.com/5680b5bdb4c31365df3342e07cb358027698748c24682dbd4476d6e8cc3e9e82","tier":"starter_2024","role":"editor"},{"type":"individual","id":"ad011ae0dc79cf45","login":"d8abased","name":"the d8a team","avatar_url":"https://avatars-next.observableusercontent.com/70386b934552f1ef82ce5a323c14a14824b8e72ac7d241df9ecb75c85c27608b","tier":null,"role":"editor"}],"comments":[],"custom_thumbnail":true,"trashed":false,"subscribed":null,"forks":0,"collection":{"id":"8e2a9ac146d4c315","slug":"librela","title":"Librela","owner":{"id":"387bada7be81c746","login":"d8abased","name":"d8abased"}},"type":"notebook","body":{"title":"An Introduction to Librela sADRs","cells":[{"id":0,"value":"# An Introduction to Librela sADRs\n## A Collection of Notebooks to Visualize, Search, and Download the Suspected Adverse Drug Reaction Data for Librela","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":407,"value":"

Without data you’re just another person with an opinion.
— William Edwards Deming

","pinned":false,"hidden":false,"mode":"html","author":"$undefined","summary":"$undefined"},{"id":375,"value":"---","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":4608,"value":"renderMenu()","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined"},{"id":4,"value":"The most comprehensive, official, and timely source of suspected adverse drug reactions (sADRs) for _Librela_¹ is the European Medicines Agency’s [EudraVigilance Veterinary Database of Suspected Adverse Drug Reaction Reports](https://www.adrreports.eu/vet/en/index.html), colloquially known as *EVVet*. \n\nEVVet tracks reported sADRs from the following countries where Librela is marketed:","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined"},{"id":1625,"value":"\n\n

\n🇦🇩 Andorra 🇦🇺 Australia 🇦🇹 Austria 🇧🇪 Belgium 🇧🇷 Brazil 🇧🇬 Bulgaria 🇨🇦 Canada 🇰🇾 Cayman Islands 🇨🇱 Chile 🇨🇴 Colombia 🇭🇷 Croatia 🇨🇿 Czech Republic 🇩🇰 Denmark 🇩🇴 Dominican Republic 🇪🇨 Ecuador 🇪🇪 Estonia 🇫🇮 Finland 🇫🇷 France 🇩🇪 Germany 🇬🇷 Greece 🇭🇺 Hungary 🇮🇸 Iceland 🇮🇪 Ireland 🇮🇱 Israel 🇮🇹 Italy 🇯🇵 Japan 🇱🇹 Lithuania 🇱🇺 Luxembourg 🇲🇽 Mexico 🇳🇱 Netherlands 🇳🇨 New Caledonia 🇳🇿 New Zealand 🇳🇴 Norway 🇵🇱 Poland 🇵🇹 Portugal 🇸🇬 Singapore 🇸🇮 Slovenia 🇿🇦 South Africa 🇪🇸 Spain 🇸🇪 Sweden 🇨🇭 Switzerland 🇹🇭 Thailand 🇬🇧 United Kingdom 🇺🇸 United States\n

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