2c:null 2d:["$","title",null,{"children":"USMdiff \n [code]\n [YouTube]\n [doc] | Jonas Almeida | Observable"}] 32:[] 30:{"id":"6a4eb5d85b08eb9e","slug":"usmdiff","title":" USMdiff \n [code]\n [YouTube]\n [doc]\n ","thumbnail":"39e4b2ce51c3b9080e7bb26a9dc80f29fb44b8436a9d5059b1fe8eaf9880c20d","access_level":"public","create_time":"$D2022-12-23T21:01:47.016Z","update_time":"$D2023-02-23T22:22:28.976Z","view_time":null,"first_public_time":"$D2022-12-23T21:01:47.016Z","has_unpublished_edits":null,"fork":false,"stars":0,"starred":false,"owner":{"type":"team","id":"0f2e596d5bd6ef6e","login":"episphere","name":"Jonas Almeida","avatar_url":"https://avatars-next.observableusercontent.com/3a0ff5abff6da0cdbd100da305ba323e12d43c8fcb7604275e6c72591db9dc69","tier":"starter_2024"},"version":89,"publish_version":null,"role":null,"authored":false,"authors":[{"type":"individual","id":"4355fe13cb71b11d","login":"episphere","name":"Jonas Almeida","avatar_url":"https://avatars-next.observableusercontent.com/3a0ff5abff6da0cdbd100da305ba323e12d43c8fcb7604275e6c72591db9dc69","tier":null}],"members":[{"type":"individual","id":"4355fe13cb71b11d","login":"episphere","name":"Jonas Almeida","avatar_url":"https://avatars-next.observableusercontent.com/3a0ff5abff6da0cdbd100da305ba323e12d43c8fcb7604275e6c72591db9dc69","tier":null,"role":"editor"}],"comments":[],"custom_thumbnail":false,"trashed":false,"lapsed":null,"subscribed":null,"forks":0,"collection":null,"type":"notebook","body":{"titling":"auto","title":" USMdiff \n [code]\n [YouTube]\n [doc]\n ","cells":[{"id":0,"value":"

USMdiff ^{\n [code]\n [YouTube]\n [doc]\n}

\n\nThis is the companion notebook to the USMdiff paper, included in the manuscript as supplementary material. As indicated under \"Availability\", the open-source library is kept at https://github.com/usm/diff. ","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"","database":"$undefined"},{"id":45,"value":"### Loading USMdiff module\nES6 module import mechanism is preferred. Note that when the conventional script tag loading mechanism is used, i.e. https://usm.github.io/diff/USMdiff.js, that is also the mechanism engaged.","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"","database":"$undefined"},{"id":6,"value":"diff = await import(\"http://localhost:8000/diff/export.js\")\n//diff = await import(\"https://usm.github.io/diff/export.js\")","pinned":true,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"$undefined","database":"$undefined"},{"id":65,"value":"Isolating the USM class for convenience","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"","database":"$undefined"},{"id":67,"value":"USM = diff.USM","pinned":false,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"$undefined","database":"$undefined"},{"id":10,"value":"u = new USM()","pinned":true,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"$undefined","database":"$undefined"},{"id":36,"value":"USM_ = (await import(\"http://localhost:8000/diff/export.js\")).USM","pinned":true,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"$undefined","database":"$undefined"},{"id":75,"value":"new USM(\"asdfadfasdfasdfad\")\n","pinned":true,"hidden":false,"mode":"ojs","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"$undefined","database":"$undefined"},{"id":78,"value":"### TP53 mutation\nThe database of TP53 mutations kept at NCI/DCEG describes ","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"","database":"$undefined"},{"id":84,"value":"

\n## Footnotes\nMiscellaneous notes\n

","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"","database":"$undefined"},{"id":82,"value":"TP53 sequence: https://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?id=568815581&db=nuccore&report=fasta&extrafeat=null&conwithfeat=on&hide-cdd=on&retmode=html&withmarkup=on&tool=portal&log$=seqview\n\nSARS sequence https://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?id=1798174254&db=nuccore&report=fasta&extrafeat=null&conwithfeat=on&hide-cdd=on&retmode=html&withmarkup=on&tool=portal&log$=seqview","pinned":false,"hidden":false,"mode":"md","author":"$undefined","summary":"$undefined","providerMetadata":"$undefined","attachments":"$undefined","output":"","database":"$undefined"}],"files":"$W32","stdlib":"1"}} 31:"$30:body"