27:null 28:["$","title",null,{"children":"Meta analysis: Cognitive and Physical interventions in older adults | Kyu Lee | Observable"}] 2d:Tcd1,html`

Background: There is increasing interest at the clinical level and at the policy level in the use of behavioral interventions - specifically Cognitive Training (CT), Physical Exercise (PE), and Nutrition (NU) to improve brain health and cognitive function in older adults.

Problem: Direct comparisons of the relative efficacy of various classes of behavioral interventions are challenging because meta-analyses typically focus on a single type (CT, PE, or NU) and use different inclusion criteria and analytical methods. Clinicians and policy-makers lack comprehensive comparable data to recommend interventions to patients and to define overall clinical guidelines.

Objective: Develop an open-source database of randomized controlled trials of CT, PE, and NU interventions with a common set of inclusion criteria and evaluate the relative efficacy of various classes of interventions with meta-analysis.

Search CLASSES: We reviewed the top 50 meta-analyses for each intervention type. The search identified 853 publications, of which 576 were excluded. 247 publications comprising 309 clinical trials were included in the analysis. A detailed description of the search strategy is provided on the accompanying website.

DROP QR
CODE
HERE

`2e:T679,html`

The Influence of Control Class on Intervention Efficacy

• Cognitive Training: Net effect sizes are numerically higher in trials with active controls (0.33) than passive controls (0.23).

• Physical Exercise: Net effect sizes are significantly lower ($p=0.0237$) in trials with active controls (0.14) than passive controls (0.29).

• Nutrition: Net effect sizes are similar in trials with active (0.18) and passive (0.14) controls.

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