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Contraindications:
Ongoing or uncontrolled bleeding Uncorrected coagulopathy (PLT < 50,000; INR> 1.5; or PTT>2x cpmtrp;) Suspected or known paraspinal hematoma History of heparin-induced thrombocytopenia Intracranialmonitoring (EVD/Bolt) – CNS drain (epidural catheter / other) Rick for major surgical bleeding (clear all anticoagulation with surgeon)

Severe Thrombophilia:
Anti-thrombin III Deficiency Homozygous Factor V Leiden Mutation Homozygous Prothrombin Gene Mutation Protein C Deficiency Protein S Deficiency

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