The avatar for @aaronge-2020
Aaron Ge
Public
Edited
Jan 2
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module = import("https://episphere.github.io/msig/main.js")
// module = import("http://127.0.0.1:5500/main.js")
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mSigSDK = module.mSigSDK
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mutationalSignatures = await mSigSDK.mSigPortal.mSigPortalData.getMutationalSignaturesData("WGS", "COSMIC_v3_Signatures_GRCh37_SBS96", "SBS", 96, 10000)
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mutationalSignaturesExtracted = await mSigSDK.mSigPortal.mSigPortalData.extractMutationalSpectra(mutationalSignatures, "signatureName")
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patientData = await mSigSDK.mSigPortal.mSigPortalData.getMutationalSpectrumData(
"PCAWG",
null,
"WGS",
"Lung-AdenoCA",
"SBS",
96,
);
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extractedPatientData = mSigSDK.mSigPortal.mSigPortalData.extractMutationalSpectra(patientData)
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nnlsExposures = mSigSDK.signatureFitting.fitMutationalSpectraToSignatures(mutationalSignaturesExtracted, extractedPatientData, { exposureThreshold: 0.02, exposureType: "absolute" })
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mSigSDK.signatureFitting.plotDatasetMutationalSignaturesExposure(nnlsExposures, "exposureHeatmap", true, "PCAWG", true, "custom")
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mSigSDK.signatureFitting.plotPatientMutationalSignaturesExposure(nnlsExposures["SP51037"], "exposureGraph", "SP50263")
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