The avatar for @samisaf
Sami Safadi
Public
Edited
Feb 10, 2022
2 forks
1 star
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/**
* Uses Henderson–Hasselbalch's equation to calculate pH based on serum HCO3 and PCO2
*/
function HH_pH(PCO2, HCO3=24, pKa=6.1, alpha=0.03){
let pH = pKa + Math.log10(HCO3/(alpha * PCO2))
return pH
}
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/**
* Uses Henderson–Hasselbalch's equation to calculate pCO2 based on serum HCO3 and pH
*/
function HH_PCO2(pH, HCO3, pKa=6.1, alpha=0.03){
let pCO2 = HCO3 / (10**(pH-pKa) * alpha)
return pCO2
}
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/**
* Takes a tidal volume(TV), respiratory rate(RR), and dead space volume (TVd)
* Returns alveolar ventilation(VA), and dead space ventilation(VD)
*/
function MV(TV, RR, TVd=0){
let TVa = TV - TVd
let VD = TVd * RR
let VA = TVa * RR
return [VA, VD]
}
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/**
* Calculates new PCO2 based on old PCO2, and changes in tidal volume, and respiratory rate accounting for dead space
*/
function newPCO2(TV_old, RR_old, PCO2_old, TV_new, RR_new, TVd){
let [VA_old, VD_old] = MV(TV_old, RR_old, TVd)
let [VA_new, VD_new] = MV(TV_new, RR_new, TVd)
let PCO2_new = VA_old * PCO2_old / VA_new
return PCO2_new
}
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